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Transmission
of HIV
HIV
is readily transmitted through sexual contact, as well as exposure to
blood and/or blood products and certain body fluids. Studies indicate
the highest percentage of HIV transmissions occur during sex acts where
body fluids are exchanged. Body fluids include blood, blood products,
saliva, tears, urine, semen, vaginal secretions, breast milk, and -perspiration.
The use of contaminated needles by injecting drug use is the second most
frequent route of transmission of HIV.
Current
perspectives on the transmission and prevention of HIV are based on two
distinct findings. First, it is accepted that HIV can be transmitted through
infected blood or semen. However, the production of overt disease by the
transmitted virus seems to demand additional conditions such as a significant
level of infection or repeated exposure. Thus, HIV spreads primarily through
persons who engage in risky behaviors where these conditions are most
likely to be met.
HIV
can also be transmitted from pregnant women to their babies during the
birthing process.

Preventing
the Spread of HIV
People's
concerns regarding this life-threatening and incurable disease are often
out of proportion to the actual risks revealed by scientific studies.
The known facts are now being presented by advocacy groups, counseling
centers, neighborhood education programs, mass communication media and
other concerned individuals in an intense effort to educate the general
public concerning the facts about AIDS and HIV. Facts that are emphasized
to reduce misinformation about AIDS include the following:
- HIV is not spread by shaking hands or otherwise touching someone
who is HIV positive.
- HIV is not spread by insect bites such as those inflicted by
mosquitoes.
- HIV is not spread by sharing eating utensils with someone who
is HIV positive.
- HIV is not spread by sharing drinking glasses or cups.
- HIV is not spread by kissing, although some sources recommend
against "deep kissing" of an infected person.
To
prevent HIV infection, the CDC offers the following suggestions:
- Do not have sex with an infected person.
- Do not share needles with an infected person.
- Avoid any behavior that might result in contact with blood, semen,
vaginal secretions, or body fluids with visible blood. Specifically,
avoid sex with anyone who might be infected with HIV, and do not share
"injecting drug works."
Specific
prevention measures applicable to personal sexual practices and injecting
drug use (IDU) include:
- To prevent sexual transmission of HIV, abstain from sex with an infected
person.
- Ask about the sexual history of current and future sex partners.
- Reduce the number of sex partners to minimize the risk of HIV infection.
- Always use a condom from start to finish during any type of sex (vaginal,
anal, and oral). Use latex condoms rather than natural membrane condoms.
If used properly, latex condoms offer greater protection against sexually
transmitted diseases, including HIV. Dental dams may also be used during
oral sex.
- Use only water-based lubricants. Do not use saliva or oil-based lubricants
such as petroleum jelly or vegetable shortening. If you decide to use
a spermicide along with a condom, it is preferable to use spermicide
in the vagina according to manufacturer's instructions.
- Avoid anal or rough vaginal intercourse. Do not do anything that would
tear the skin or moist lining of the genitals, anus, or mouth and cause
bleeding.
- Condoms should be used even for oral sex.
- Avoid deep, wet, or "French" kissing with an infected person.
Even though transmission of HIV has not been documented by this method,
possible trauma to the mouth may occur, which could result in the exchange
of blood.
- Avoid alcohol and illicit drugs. Alcohol and drugs can impair your
immune system and your judgment. Do not share needles, syringes, cookers
- "works." If these items are shared, they should be disinfected
with bleach.
- Do not share personal items such as toothbrushes, razors, or devices
used during sex that may be contaminated with blood, semen, or vaginal
fluids.
- If you are infected with HIV or have engaged in sex or needle-sharing
behaviors that lead to infection with HIV, do not donate blood, plasma,
sperm, body organs, or tissues.
Reducing
high-risk behaviors through educational efforts is still the best way
to prevent HIV infections.
Diagnostic
Tests
Testing
is an important tool in the nation's efforts to curtail the spread of
HIV. Testing allows researchers to track the course of the epidemic, and
provides information to help in developing prevention strategies and allocating
resources for HIV-related services. Counseling, which should be provided
before and after testing, provides a unique opportunity to educate individuals
about HIV, including risks; how to avoid infection; and, if they are positive,
how to protect others, as well as treatment options and follow-up.
In
addition to its value as a prevention tool, testing is the first step
in helping people who are infected to receive appropriate treatment. Early
detection of HIV, followed by administration of certain drug combinations,
can greatly improve both the quality and length of life. It also plays
a vital role in reducing the transmission of HIV from mother to infant.
Pregnant women who are tested and find out they are infected have the
opportunity to take drugs that may prevent the infant from becoming infected.
The
primary means of documenting HIV infection is by HIV antibody testing
and viral culture. Viral cultures are both expensive and time consuming,
so antibody testing is the method of choice for rapid and inexpensive
confirmation of HIV exposure. You should be aware that antibody testing
alone is not diagnostic for AIDS. As early as 1985 the enzyme-linked immunoabsorbent
assay (ELISA) test was available. It is a commercial test used for many
purposes other than the detection of HIV antibodies. The ELISA test is
not a test for AIDS, and it does not detect the actual virus; it only
indicates the presence of antibodies to HIV.
The
reliability of the ELISA test is high, and it is considered sensitive
and specific. The Centers for Disease Control and Prevention estimates
the sensitivity and specificity of the licensed ELISA tests are 99% or
higher when the double ELISA test is done.
The
Western blot technique uses electrophoresis to separate viral antigens
and measures serum antibody reaction to specific viral proteins (core
and envelope proteins).
HIV
testing can also be done with saliva. The FDA has approved the first test
that uses a saliva sample rather than blood. Marketed under the name of
Ora Sure, the test kit consists of a cotton swab on a stick and
a vial containing a preservative solution. The client holds the swab between
the lower cheek and gum for two minutes; then, the entire stick is put
into the vial and sent to the lab. The test is not intended or approved
for home use.
Because
the test produces false negatives or false positives in up to 2% of clients,
it is considered less accurate than the standard blood test for HIV. As
a result, it is not approved for screening potential blood donors. Furthermore,
the FDA requires positive results to be confirmed by a blood test.
A
new alternative in HIV testing can now be performed conveniently, in the
comfort and privacy of the home. Home Access HIV testing provides
fast test results that are just as reliable as those used by doctors,
hospitals, and public clinics. Everything needed for an accurate result
is included.
Also,
the option to speak with a professional counselor 24 hours a day, 7 days
a week is available. This self-administered test is completed in four
short steps:
- Call to register a code number and receive pre-test information.
- Collect a blood sample by pricking a finger with a safety lancet.
Then apply blood to a specimen collection card.
- Package the specimen card and ship to the Home Access laboratory.
- Call for the results. Blood is screened using the ELISA system. If
this screen is positive, a more specific confirmatory test, Immunofluorescence
Assay (IFA) will be used.
Home
Access guarantees anonymity with every call. No names are ever associated
with a test result. This test kit can be ordered over the Internet at
www.hiv-test.net.
FYI:
Fewer than 40% of people in the U.S. who are potentially at risk for HIV
infection has been tested. You should be aware that neither the CDC nor
WHO has endorsed universal mandatory testing at any time. The suggestion
has also been rejected by the American Nurses Association (ANA).
Caregiver
Concerns
Despite
the myths and half-truths that exist concerning HIV and AIDS, if recommended
precautions are taken and the caregiver doesn't succumb to unrealistic
fears, adequate protection from the virus will be achieved. The best approach
to avoid contracting AIDS or the transmission of HIV is to heed the CDC's
recommendation of Standard Precautions: to treat every client as though
they are HIV positive. This recommendation is repeated numerous times
within this course and its importance cannot be overemphasized.
OSHA
law, which protects healthcare workers, requires the practice of Universal
Precautions. CDC has broadened these requirements to include taking precautions
with ALL body fluids and substances. The expanded recommendations are
known as Standard Precautions.
Standard
Precautions
The
experience of treating a client with AIDS often presents the health professional
with a dilemma. The question often arises of how to protect others and
ourselves in the daily requirements of our responsibility to clients,
without contributing to perceptions of discrimination. Using the Standard
Precautions suggested by the CDC, you can protect yourself and others
as you provide care by treating all clients equally.
The
Standard Precautions requirement is, of course, applicable in emergency
care situations or in those areas where there is a high risk of exposure
to blood or body fluids. It is in those situations that the risk of being
exposed to contaminated blood or body fluids is greatest.
The
Precautions are designed to prevent the transmission of pathogens from
all body substances such as:
- blood
- all body fluids, secretions, and excretions (except perspiration)
regardless of whether or not they contain visible blood
- non-intact skin
- mucous membranes
Standard
Precautions
Handwashing
- Hands should be washed for 15 seconds using soap
and water, rinsing, and using paper towels to turn off the faucet. Hands
must be washed before any patient contact and after any contact with body
substances as listed above, as well as any contaminated items or linens
used by patients. Hands must be washed before and after the use of protective
gloves, after the caregiver's use of the toilet, and before and after
the caregiver eats or takes beverages.
You
should also be aware of the dangers of placing fingers or other items
in the mouth, rubbing the eyes, or eating and drinking in any environment
that may be contaminated.
Handwashing
is the single most important factor in preventing HIV and other diseases.
Barrier
Precautions
-
Healthcare
professionals should always use barrier precautions to prevent skin
or mucous membrane exposure to blood or body fluids.

Gloves
- Latex or vinyl gloves must be worn before touching any blood, body fluids,
excretions, non-intact skin, or mucous membranes. Gloves should be changed
between patients, and between tasks for the same patient if in contact
with material that may spread the organisms to other body parts. They
should also be worn when performing venipuncture or other vascular access
procedures. With the possibility of undetectable holes in exam gloves,
and in an effort to improve overall safety, many health professionals
elect to double-glove for the above procedures. Always examine gloves
closely before wearing.

Protective
Equipment - Use
a mask and eye protection or a face shield when performing procedures
where splashing of blood, body fluids, or secretions and excretions may
occur.

Gowns
-
Wearing
a clean, non-sterile gown can protect the caregiver from soiling of clothing
during patient procedures where body fluids may contaminate.
Saliva
- Although
it has not been specifically implicated in the transmission of HIV, saliva
has not been removed from the list of body fluids that require the caregiver
to exercise Standard Precautions. The CDC suggests that in instances of
resuscitation, mouthpieces, resuscitation bags or other ventilation devices
should be readily available. In all clinical settings the CDC and the
American Dental Association's Council on Dental Therapeutics suggest assuming
that saliva contaminated with blood can potentially carry HIV.
Patient/Resident
Equipment -
Use Standard Precautions when handling, discarding, or cleaning any medical
equipment. Although HIV is considered fragile, (it has been shown to be
easily destroyed by exposure to common cleaning agents, and by all routine
methods of sterilization presently used in hospitals and clinics) Hepatitis
B Virus (HBV) may live for several weeks on equipment, furniture, and
linens.
Environment
- Facility
policy should dictate routine and proper cleaning and disinfecting of
walls, floors, bed and bedside furniture, and any other frequently used
items.

Sharps
and Needle Stick Protection
-
While
HIV infection is rare among caregivers, there is the potential for exposure
any time a puncture wound occurs from a contaminated needle, lancet, or
surgical instrument. Special care should be taken when using, caring for,
disinfecting, or cleaning these items. Needles should NEVER be recapped
with both hands, purposely bent, broken, manipulated, or removed from
disposable syringes by hand.
After
use, disposable syringes and needles, scalpel blades, and all other sharps
that are to be disposed of should be placed in a puncture-resistant container
that is placed as close to the use area as is practical. Large bore reusable
needles should be placed into a puncture-resistant container and then
transported to the nearest reprocessing area. Housekeepers and other environmental
workers must adhere to the same precautions when disposing of contaminated
rubbish.
Specimens
should be placed in leak-proof containers or bags with a biohazard warning
label. Appropriate procedures must be followed for cleaning and sterilizing
instruments. Never re-use disposable equipment.
About
one out of every four needle stick injuries involves IV therapy equipment.
Many injuries result during disassembly, but they may also occur during
any of the steps of the assembly/use/discard process, including insertion
into drip chambers, injection ports and IV bags.
You
should be aware that needles attached to discontinued IV lines may also
present a problem. The Federal government offers sanctions to discourage
health facilities from continuing to use conventional devices. It is documented
that the Occupational Safety and Health Administration (OSHA) has levied
fines against hospitals for failure to evaluate and consider the adoption
of engineering controls, equipment or devices that reduce the risk of
needle stick injury.

Invasive
Procedures
Some
procedures you perform will pose a greater threat of contracting HIV than
others. Along with OSHA, the CDC has supplied specific information concerning
invasive procedures. "Characteristics of exposure-prone procedures
include digital palpation of needle tip in a body cavity or the simultaneous
presence of the healthcare worker's fingers and needle or other sharp
instrument or object in a poorly visualized or confined anatomic site.
The performance of exposure-prone procedures presents a recognized risk
of percutaneous injury... If such an injury occurs, blood is likely to
contact the client's body cavity, subcutaneous tissues, and/or mucous
membranes."
An
invasive procedure is defined as a surgical entry into tissues, cavities,
or organs, or repair of major traumatic injuries:
- In the operating room, delivery room, emergency department, or outpatient
setting to include both physician and/or dental offices.
- Cardiac catheterization and angiographic procedures.
- A vaginal or cesarean delivery, or other obstetric procedures where
bleeding may occur.
- Manipulation, cutting or removal of any oral or perioral tissues,
including tooth structure, where bleeding occurs or the potential for
bleeding exists.
The
standard blood and body fluid precautions are recommended by both the
CDC and OSHA and should be the minimum for all invasive procedures.

Implementing
the Recommended Precautions
Healthcare
facilities should ensure that policies exist for the implementation of
recommended precautions and that employees are aware of these policies.
Most state boards of nursing now require that HIV/AIDS education be completed
as a condition for renewal of nursing licenses.
Policies
should exist for:
- Education of all employees at the initial orientation, including students
and trainees. The orientation should include but not be limited to epidemiology,
modes of transmission, and the prevention of the transmission of HIV
and other blood-borne pathogens. The need for routine use of the standard
blood and body fluid precautions in the care of all clients should be
emphasized.
- Provision, at the employer's expense, of all equipment, supplies and
personal vaccinations necessary to minimize the risk of infection with
HIV and/or other blood-borne pathogens.
- Provision of a monitoring program that assures all the recommended
protective measures are followed by the persons concerned. If there
is a problem with an individual(s) who will not adhere to the recommended
program or procedures, counsel them first, educate and retrain. If they
still persist, appropriate disciplinary action may be necessary and
should be taken.
- Professional associations and labor organizations can use continuing
education to emphasize their support and the need for caregivers to
follow the recommended precautions.
Controlling
HIV in the Environment
Disinfection
and Sterilization
Standard
procedures currently recommended for disinfection and sterilization are
adequate to control HIV. These include the procedures and requirements
of hospitals, clinics (medical and dental), offices, hemodialysis centers,
and long-term care facilities. HIV has not posed any special requirements
or procedures for the caregiver in order to achieve proper sterilization
or disinfection within the professional environment.
They
have, however, emphasized the following factors to be included in standard
infection control practice:
- Sterilize all equipment and/or devices that enter the client's vascular
system or other areas that are normally sterile.
- All devices and equipment that contact intact mucous membranes but
do not penetrate the client's body surfaces should be sterilized when
possible. If they cannot be sterilized before being used for each client,
they should undergo high-level disinfection.
- Equipment or devices that do not contact the client's skin, or contact
only intact skin of the client, need to be cleaned with a detergent
or as recommended by the manufacturer.
When
preparing medical devices or instruments requiring disinfection or sterilization,
thoroughly clean them and then expose them to a germicide as the manufacturer's
instructions allow.
Be
especially careful to adhere to the manufacturer's special instructions
as they apply to the compatibility of the device or instrument with the
germicidal cleaning agent.
Concerning
the survival of HIV in the environment, the CDC has stated that:
- HIV does not survive well outside the body.
- HIV has to be grown in large amounts to be studied in laboratories.
Although HIV has been kept alive under certain laboratory conditions,
medical authorities agree that the virus does not survive well in the
environment.
To
put things into perspective, 1 milliliter (ml) of blood from a hepatitis
B infected person may contain more than 100 million infectious viral particles.
In a dried state, hepatitis B virus (HBV) may remain viable on surfaces
for up to one week, and possibly longer. In contrast, the concentrations
of HIV in the blood of infected persons are much lower. Neither HBV nor
HIV is able to reproduce outside the human body, unlike bacteria or fungi,
which do so under suitable conditions. In laboratory studies of HIV and
HBV, it was biologically necessary for these viruses to infect specific
human cells to complete their life cycles and thereby reproduce themselves.
HIV
has been thought to be rapidly inactivated after it has been exposed to
commonly used germicides at concentrations much lower than used in the
average medical or dental practice. A 10% solution of household bleach
prepared daily is an inexpensive, effective germicide when used to inactivate
HIV. These concentrations are effective depending entirely on the amount
of organic material present on the instrument, object, device or surface.
The
CDC and OSHA continue to recommend the 10% bleach solution for disinfection.
There are also commercial chemical germicides available that may be more
compatible with certain medical devices or instruments to ensure they
do not become corroded or damaged by extended use of the 1:10 hypochlorite
dilution.

Cleaning
and Decontaminating Blood Spills and Body Fluids
To
clean and decontaminate spills of blood and other body fluids, always
use chemical germicides that are EPA approved as tuberculocidal. In client
care areas where visible material is present, it should first be removed
and then the area should be decontaminated. In instances where there are
large spills of cultured or concentrated infectious materials, as may
occur in a laboratory, first flood the area with an EPA approved germicide
and then decontaminate the area with a fresh germicidal solution. Gloves
should always be worn during cleaning and decontaminating procedures.
For
routine housekeeping, the recommended rules are applicable for HIV. Usually,
environmental surfaces such as walls, floors and other surfaces are not
associated with the transmission of infections. HIV is a fragile virus
and has been shown to be easily killed by routine disinfecting techniques,
so the frequency of scheduled cleanings does not need to be altered to
be effective against it.
When
this is considered in the context of environmental conditions in healthcare
facilities it does not require any changes in the sterilization or disinfecting
procedures now recommended for housekeeping.

Laundry
and Soiled Linen
Soiled
linen has shown to be a source of large concentrations of certain pathogenic
organisms. However, studies by the CDC have reported the risk of actual
transmission of HIV from soiled linen is negligible. In fact, the CDC
has suggested the use of hygienic principles coupled with common sense
as guidelines when handling soiled linen. Those recommendations include:
- Always wear gloves when handling soiled linen.
- Always bag soiled linen on location.
- Do not sort or rinse soiled linen in client care areas.
- Always place linen that is soiled with blood or body fluids into bags
that prevent leakage if it is to be transported.
- Wash soiled linen in 71 C. (160 F.) water for 25 minutes using a suitable
detergent.
Precautions
for Infective Waste
Hospital
waste, which requires special precautions regarding disposal in all cases,
includes microbiology laboratory waste, pathology waste and blood specimens
or blood products. Generally, infective waste should either be incinerated
or be autoclaved before it is disposed into a sanitary landfill. Bulk
blood, suctioned fluid, and secretions may be carefully poured down a
drain connected to a sanitary sewer. The sanitary sewer can also be used
to dispose of other infectious wastes if they are capable of being ground
and flushed into the sewer.

Management
of Infected Caregivers
There
have been only a few instances where HIV has been transmitted from a caregiver
to a client, but there is an ever-present possibility that it can occur
during an invasive procedure. You should be aware that the Hepatitis B
virus (HBV), another blood-borne pathogen, is more easily transmitted.
In all instances, such transmissions occurred during invasive procedures
when the caregiver sustained a puncture wound or had exudative or weeping
lesions or microlacerations that allowed the virus to contaminate instruments
or the open wounds of clients.
The
CDC is aware of 56 healthcare workers in the U.S. who have been documented
as having seroconverted to HIV following occupational exposures. Twenty-five
have developed AIDS. When the very high number of caregivers with a high
rate of exposure is considered, this number, although regrettable, represents
an extremely low occurrence of the disease. The individuals who seroconverted
include 23 nurses, 19 laboratory workers (16 of whom were clinical laboratory
workers), 6 physicians, 2 surgical technicians, 1 dialysis technician,
1 respiratory therapist, 1 health aide, 2 housekeeper/maintenance workers
and 1 embalmer/morgue technician. (CDC, HIV Surveillance Report, 12(1),
2000)

UPDATE:
MMWR 1998; 47(No.RR-7) Public Health Service Guidelines for the Management
of Healthcare Worker Exposures to HIV and Recommendations for Post-Exposure
Prophylaxis (PEP):
This
summary document updates and consolidates all previous public health service
(PHS) recommendations for the management of healthcare workers who have
occupational exposure to blood and other body fluids that may contain
HIV; it includes recommendations for HIV PEP and discusses the scientific
rationale for PEP. The decision to recommend HIV PEP must take into account
the nature of the exposure (e.g., needle stick or potentially infectious
fluid that comes in contact with a mucous membrane) and the amount of
blood or body fluid involved in the exposure. Other considerations include
pregnancy in the healthcare worker and exposure to virus known or suspected
to be resistant to antiretroviral drugs.
Assessments
of the risk for infection resulting from the exposure and the infectivity
of the source are key determinants of offering PEP. Consent from the possibly
infected patient (source of HIV) must also be given to test. Systems should
be in place for the timely evaluation and management of exposed healthcare
workers and for consultation with experts in the treatment of HIV when
using PEP.
Recommendations
for PEP have been modified to include a basic 4-week regimen of two drugs
(zidovudine & lamivudine) for most HIV exposures. An expanded regimen
includes the addition of a protease inhibitor (indinavir or nelfinavir)
for HIV exposures that pose an increased risk for transmission; or where
resistance to one or more of the antiretroviral agents recommended for
PEP is known or suspected.
Occupational
exposures should be considered urgent medical concerns to ensure timely
administration of PEP. Healthcare organizations should have protocols
that promote prompt reporting and facilitate access to post-exposure care.
Enrollment of healthcare workers in registries designed to assess side
effects in those who take PEP is encouraged.
Single
copies of the complete document on PEP recommendations are available from
the CDC, National AIDS Clearinghouse, PO Box 6003, Rockville, MD 20850,
by calling (800) 458-5231, or online at www.cdcnac.org.
Care
of the AIDS Client
AIDS
is a disease that presents a unique and challenging health- and life-threatening
problem for the client, as well as challenges for the caregiver. Clients
will require physical care, emotional support and counseling for a debilitating
disease. They will not only be aware that the disease is fatal, but it
also may have been transmitted to a loved one. In many cases, your clients
are faced with the fact that AIDS is a stigmatized disease. You will find
the emotional responses and requirements for help and support will vary
with the inner coping and adjusting capabilities of each individual. These
are directly related to the inner strengths, beliefs and mental health
of each client. The importance of your sincere, dedicated emotional support
to AIDS clients during this period cannot be over-emphasized.
As
the profile of AIDS clients changes to include more young people, women
and minorities, caregivers will need to develop awareness of new sets
of cultural issues that may affect the client's willingness to seek treatment,
and the probability of compliance with the plan of care. Awareness of
potential prejudices toward certain behavioral practices will remain important.
The caregiver must remember that how a person became infected is not important;
hope, compassion, and respect - not censure or condemnation - will be
key aspects of your care.
The
healthcare requirements for persons with AIDS will vary as the disease
progresses. These needs are met in a variety of ways, circumstances and
settings. During this time, the client's personal needs for providers
will also vary. Often a caregiver will be a nurse, a home-health aide,
a family member, a friend or maybe another person with AIDS.
During
the course of the disease, your client may undergo multiple hospitalizations
for treatment of acute opportunistic infections. You may be the primary
provider during these episodes.
As
the disease progresses to its terminal stages, your client's family and
friends may act as the primary care providers and perform the necessary
care in the client's home. During these periods your clients may also
require the assistance of a home-health aide.
In
the following section we will discuss some important needs and requirements
of AIDS clients in a hospital care setting.

Hospital
Care of the AIDS Client
During
early attempts to find treatment for, or at the very least control, the
disease, numerous treatment and control techniques were suggested. However,
the CDC now recommends special isolation for AIDS clients only if associated
conditions such as infectious diarrhea, tuberculosis or other communicable
diseases are present. With AIDS, these infections will often result in
severe illness due to a compromised immune system.
The
AIDS client who is admitted to the hospital will often be acutely ill,
physically debilitated and extremely apprehensive. One of your most important
roles will be to provide support and reassurance. As an initial step,
you can explain the necessity of having a complete physical examination,
as well as various other procedures and diagnostic tests. A factor of
extreme importance and concern to the client is confidentiality.
During
past decades the legislatures of many states have enacted strict HIV testing
and confidentiality laws. You must give assurance of strict confidentiality
of the information that is divulged and also assure the client that this
applies to results of all diagnostic procedures and laboratory tests.
Hospital
care for AIDS is planned as with all other clients, on the basis of assessment.
The plan will focus first on the most critical problems, which are usually
opportunistic infections and malfunctioning organs or systems. Objectives
of treatment are to:
- Identify and treat infections.
- Maintain functioning organs.
- Provide symptomatic relief.
- Identify and/or prevent complications of treatment.
- Provide compassionate emotional and physical support.
Medical/Pharmaceutical
Treatment
Medical
management of HIV disease and AIDS has changed dramatically in recent
years, primarily due to the use of powerful combination antiretroviral
therapy, often referred to as highly active antiretroviral therapy or
HAART. The new combinations of three or four antiretroviral agents usually
include two nucleoside reverse transcriptase inhibitors (NRTIs) with either
one or two protease inhibitors (PIs), or one of the nonnucleoside reverse
transcriptase inhibitors (nNRTIs). (See Tables 8 and 9)
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